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Permeability Of Hydrophilic
Beginning of paper
SUMMARY
Investigations of the integrity and transport characteristics of 2/4/A1 cells
have been done in this report. The cell line was isolated from rat fetal
intestinal epithelial cells and transfected with thermolabile SV40 large T
antigen.
These cells proliferated at 33 °C, but eliminated the antigen and ceased
proliferating at a non .... Middle of paper
.... more
accurately between the molecules of intermediate molecular weight compared to
Caco-2 cells.
These results indicated that 2/4/A1 cells could be used as a model for
hydrophilic drug absorption.
INTRODUCTION
The small intestine plays a crucial role in the absorption of drugs and
nutrients. Exogenous substances cross a series of barriers during the process
of intestinal absorption: (1) the aqueous boundary/mucus layer, (2) a single
lay ....
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Number of words: 2422
Number of pages: 9 (approx. 250 words per double-spaced page)
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