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Huntington's Disease
Beginning of paper
Background
is inherited as an autosomal dominant disease that gives
rise to progressive, elective (localized) neural cell death associated with
choleric movements (uncontrollable movements of the arms, legs, and face) and
dementia. It is one of the more common inherited brain disorders. About 25,000
Americans have it and another 60,000 .... Middle of paper .... HD patients have significantly
higher mtDNA deletionlevels than agematched controls in the frontal and temporal
lobes of the cortex. To test the hypothesis, the amount of mtDNA deletion in 22
HD patients brains was examined by serial dilution-polymerase chain reaction
(PCR) and compared the results with mtDNA deletion levels in 25 aged matched
controls. Brain tissues from three cortical regions were taken during an autopsy
(from the 22 HD ....
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Number of words: 1074 Number of pages: 4 (approx. 250 words per double-spaced page)
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